Madan Kharel

  • Madan Kharel

    Assistant Professor, Pharmaceutical Sciences

    Education

    • Ph.D. – Pharmaceutical Sciences (2010) University of Kentucky, Lexington, KY
    • Ph.D. – Biochemistry (2004) Sun Moon University, Republic of Korea
    • M.S.- Chemistry (1998) Tribhuvan University, Nepal
    • B.S.-Biology (1996) Tribhuvan University, Nepal

    Bio

    Dr. Madan Kharel, Assistant Professor, graduated with a Bachelor of Biology from Tribhuvan University, Nepal, in 1996. In 1998, he obtained a Master of Science, Chemistry, from Central Department of Chemistry, Tribhuvan University. Dr. Kharel received his Ph.D. from Sun Moon University, Republic of Korea in 2004. After two years of post-doctoral research training, he joined graduate program at the University of Kentucky, and obtained a Ph.D. in Pharmaceutical Sciences in 2010. As a research associate, and then a research assistant professor, Dr. Kharel continued his research in the area of antibiotics and anticancer drug discovery at the University of Kentucky. Dr. Kharel joined the UMES faculty in 2013. He is a member of the AACP.

    Courses Taught

    Pharm D Courses

    PHAR 510 Fundamentals of Drug Action and Metabolism

    PHAR 511 Genetic Controls of Cell Function, Cell Reproduction and Protein Synthesis

    PHAR 512 Metabolism of Carbohydrates, Lipids, and Amino acids

    PHAR 523 Endocrine System: Pharmacology and Medicinal Chemistry

    PHAR 513 Hematology and Immunology

    Graduate courses

    PSGP 801 Drug Design and Discovery I

    PSGP 803 Advanced Drug Metabolism I

    PSGP 812 Advanced Bioorganic Chemistry I

    PSGP 813 Advanced Bioorganic Chemistry II


    Scholarly activities

    Wang X, Zhang Y, Ponomareva LV, Qiu Q, Woodcock R, Elshahawi SI, Chen X, Zhou Z, Hatcher BE, Hower JC, Zhan CG, Parkin S, Kharel MK, Voss SR, Shaaban KA, Thorson JS, Mccrearamycins A-D, Geldanamycin-Derived Cyclopentenone Macrolactams from an Eastern Kentucky Abandoned Coal Mine Microbe. Angewandte Chemie International Edition, 2017, 56(11):2994-2998, PMID: 28140487

    Rochford K, Chen F, Waguespack Y, Figliozzi RW, Kharel MK, Volatile Organic Compound Gamma-Butyrolactone Released upon Herpes Simplex Virus Type -1 Acute Infection Modulated Membrane Potential and Repressed Viral Infection in Human Neuron-Like Cells. Zhang Q, Martin-Caraballo M, Hsia SV. PLoS One. 2016, 18;11(8):e0161119, PMID: 27537375

    Tejada FR, Kharel MK, Drugs Used in Tuberculosis and Leprosy, Side Effects of Drugs Annual, 2016, 38 283-293

    Singh S, Michalska K, Bigelow L, Endres M, Kharel MK, Babnigg G, Yennamalli RM, Bingman CA, Joachimiak A, Thorson JS, Phillips GN Jr. Structural Characterization of CalS8, a TDP-α-D-Glucose Dehydrogenase Involved in Calicheamicin Aminodideoxypentose Biosynthesis. Journal of Biological Chemistry, 2015, 290(43):26249-26458, PMID: 26240141

    Elshahawi SI, Shaaban KA, Kharel MK, Thorson JS. A Comprehensive Review of Glycosylated Bacterial Natural Products. Chemical Society Review, 2015, 44(21):7591-7697, PMID: 25735878

    Wang X, Shaaban KA, Elshahawi SI, Ponomareva LV, Sunkara M, Copley GC, Hower JC, Morris AJ, Kharel MK, Thorson JS. Mullinamides A and B, New Cyclopeptides Produced by the Ruth Mullins Coal Mine Fire Isolate Streptomyces sp. RM-27-46, 2014, Journal of Antibiotics, 67(8):571-575, PMID: 24713874

    Click the link for the articles listed on the PubMed

    Areas of Interest and/or Experience

    • Combinatorial biosynthesis and biosynthetic pathway engineering
    • Enzyme evolution and novel enzymatic catalysis
    • Natural product drugs discovery (main focus anti-infective and anti-cancer agents)
    • Environmental bioremediation of toxic chemicals

    Current Research Activities

    • Isolation and characterization of new microbial natural products
    • Elucidation/identification of novel enzymatic function.
    • Development of eco-friendly approach for the bio-remediation of halogenated environmental pollutants Collaborator: Dr. Marcos Cheney, Dept. of Natural Sciences, Univ of MD Eastern Shore