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Patrice Ayotunde

  • Dr. Patrice Jackson-Ayotunde

    Patrice L. Jackson-Ayotunde
    Associate Professor, Pharmaceutical Sciences

    Richard A. Bernstein Endowed Professor


    • Postdoctoral Fellow – Drug Discovery Program, Georgetown University, Washington, DC
    • Ph.D. – Pharmaceutical Sciences (2009) Howard University, Washington, DC
    • M.S. – Organic Chemistry (2003) Tennessee State University, Nashville, TN
    • B.S. - Chemistry (2000) LeMoyne-Owen College, Memphis, TN


    Dr. Jackson-Ayotunde’s research laboratory engages in early drug discovery and development of novel anticonvulsant analogs as potential agents for the treatment of drug-resistant epilepsy.  Her laboratory works very closely with the Epilepsy Therapy Screening Program (ETSP) at the National Institute of Neurological Disorders and Stroke, NIH. Dr. Jackson-Ayotunde has a drug library of compounds that have been evaluated by ETSP for anticonvulsant activity in their induced-seizure animal models. Dr. Jackson-Ayotunde also collaborates with the National Institute of Mental Health (NIMH) Psychoactive Drug Screening Program (PDSP) led by Dr. Bryan Roth’s lab at the University of North Carolina Chapel Hill. She truly enjoys working with students. Dr. Jackson-Ayotunde has trained and mentored several graduate, professional, and undergraduate students. Dr. Jackson-Ayotunde patent entitled N-Phenyl and N-Benzyl Enaminones and Methods For Using Same was approved by the United States Patent and Trademark Office on April 3, 2018. She has published several articles in refereed journals and a book chapter. She annually attends and presents her research at national scientific meetings.

    Dr. Jackson-Ayotunde was named a Mentoring Institute for Neuroscience Diversity Scholar (MINDS) for 2016-2017, and the Emerging Scholar of 2015, Diverse: Issues In Higher Education Magazine published in Nov 2014. In 2014 she was awarded the Outstanding Invention Award from The University of Maryland, Office of Technology Commercialization and the UMES Graduate School Promising Scholar Award. Dr. Jackson-Ayotunde was awarded SP-1 Professor of the Year for 2011-2012 academic year. Dr. Patrice Jackson-Ayotunde has been selected by an external review committee to serve as the Richard Bernstein Professor for a period of three years.  

    She serves as the Faculty advisor for the Pharmacy Student Government Association and the UMES AAPS Student Chapter. Dr. Jackson-Ayotunde is currently a member of the American Epilepsy Society, the American Association of Pharmaceutical Scientists, and the American Association of Colleges of Pharmacy.

    Team Taught Courses


    PHAR 510: Fundamentals of Drug Action and Metabolism

    PHAR 520: Principles of Neurobiology and Neuropharmacology

    PHAR 525: CNS Pharmacology and Medicinal Chemistry (Course coordinator)

    PHAR 521: Cardiovascular, Renal, and Pulmonary Systems Pharmacology and Medicinal Chemistry

    PHAR 522: Gastrointestinal and Genitourinary Pharmacology and Medicinal Chemistry

    PHAR 523: Endocrine System: Pharmacology and Medicinal Chemistry

    PHAR 513: Hematology and Immunology

    Pharmaceutical Sciences Graduate Program

    PSGP 709/809: Seminar (Course coordinator)

    PSGP 801: Drug Design and Discovery I

    PSGP 802: Drug Design and Discovery II (Course coordinator)

    PSGP 803: Advanced Drug Metabolism I

    PSGP 804: Advanced Drug Metabolism II

    Dr. JA Lab Mission Statement

    Dr. JA Lab engages in early drug discovery and development of novel anticonvulsant analogs as potential agents for the treatment of drug-resistant epilepsy. By using innovative drug design, organic synthetic methodology, molecular targeting, and in vivo testing in seizure-induced models, we aim to advance the drug profile of promising candidates. We work in collaboration with researchers from diverse scientific backgrounds to achieve our overarching goal of developing a safe therapeutic for epileptic patients to live life seizure free.

    Scholarly Activities

    Jackson-Ayotunde, P.L.; Harper, T. N-Phenyl and N-Benzyl Enaminones and Methods For Using Same.
    U.S. Patent No. US 9,932,302 B1. April 3, 2018

    Amaye, I., Whittington, Heinbockel, T., Wang, Z., Woods, J., Martin, M., Jackson-Ayotunde, P. L.; “6 Hz Active Anticonvulsant Fluorinated N-Benzamide Enaminones and Their Inhibitory Neuronal Activity.” Int. J. Environ. Res. Public Health2018, 15, 1784; doi:10.3390/ijerph15081784

    Dlugos, D., Worrell, G., Davis K., Stacey, W., Szaflarski, J., Kanner, A., Sunderam, S. Rogawski, M., Jackson-Ayotunde, P., Loddenkemper, T., Diehl, B., Fureman, B., Dingledine, R.; “2014 Epilepsy Benchmarks Area III: Improve Treatment Options for Controlling Seizures and Epilepsy-Related Conditions Without Side Effects.” Epilepsy Currents, 2016, 16, 192-197.

    Thomas Heinbockel, Ze-Jun Wang, and Patrice L. Jackson-Ayotunde; Allosteric Modulation of GABAA Receptors by an Anilino Enaminone in an Olfactory Center of the Mouse Brain. Pharmaceuticals. [Online] 2014, 7(12),1069-1090 

    Jackson-Ayotunde, P. L., Alexander, M. S., Edafiogho, I. O., Scott, K. R. NMR of the Enaminones. In Structure-Activity Relationship Studies in Drug Development by NMR Spectroscopy; Rahman, A. and Choudhary, I., Editors;  Bentham e-books: 2014; Vol. 2; [Online early access] DOI: 10.2174/97816080592011140201. 

    Alexander, S. Mariano, Harkless, John, Butcher, J. Raymond, Scott, K.R., and Jackson-Ayotunde, L. Patrice;Enaminones 11. An Examination of Some Ethyl Ester Enaminone Derivatives as Anticonvulsant Agents”, Bioorganic and Medicinal Chemistry, 2013, 21, 3272-3279. 

    Jackson, P. L., Hanson, C. D., Farrell, A. K., Raymond, B. J., Stables, J.P., Eddington, N.D., Scott, K. R.; “Enaminones 12. An Explanation of Anticonvulsant Activity and Toxicity per Linus   Pauling's Clathrate Hypothesis”, European Journal of Medicinal Chemistry, 2012, 51, 42-51.

    Jackson. P. L., North, H., Alexander, M. S., Assey, G. E., Scott, K. R., Butcher, R. J.; “3-(4-Chlorobenzenesulfonamido)-5-methylcyclohex-2-en-1-one”, Acta. Cryst., 2011, E67, 2272-2273.

    Wang, Z., Sun, L., Jackson, P. L., Scott, R. K., Henibockel, T; “A Substituted Anilino Enaminone Acts as a Novel Positive Allosteric Modulator of GABAA Receptors in the Mouse Brian”; Journal of Pharmacology and Experimental Therapeutics, 2011, 336 (3), 916-924.

    Jackson, P. L., Scott, K. R., Southerland, W. M., Fang, Y; “Enaminones 8. CoMFA and CoMSIA Studies on Some Anticonvulsant Enaminones”, Bioorganic and Medicinal Chemistry, 2009, 17, 133-140.

    Edafiogho, I.O, Kombian, S. B., Anathalaskshmi, K. V. V., Salama, N. N., Eddington, N. D., Wilson, T. L., Alexander, M. S., Jackson, P. L., Hanson, C. D., Scott, K. R.; “Enaminones: Exploring Additional Therapeutic Activities”, J. Pharm. Sci.., 2007, 96, 2509-2531.

    Okoro, C. O., Fadeyi, O. O., Jackson, P. L., Richmond, R. L., Farmer, T.; “Synthesis of fluorinated cyclic s-trans vinylogous acid and amide ester derivatives”, Tetrahedron Letts, 2006, 47, 7451-7454.

    Maneno, M. K., Lee, E., Wutoh, A. K., Zuckerman, I. H., Jackson, P., Lombardo, F. A., Scott, K. R., Xue, Z.; “National Patterns of Dementia Treatment among Elderly Ambulatory Patients”, J Nat’l Med Assoc, 2006, 98, 430-435.

    Wilson, T. L., Jackson, P. L., Hanson, C. D., Xue, Z., Eddington, N. D., Scott, K. R.; “QSAR of the Anticonvulsant Enaminones; Molecular Modeling Aspects and Other Assessments, Medicinal Chemistry, 2005, 1, 371-381.

    Areas of Interest and/or Experience

    • Drug design and discovery, Medicinal Chemistry, and Computational Chemistry

    Current Research Activities

    • Synthesis and evaluation of novel enaminones as potential agents for pharmacoresistant epilepsy. Collaborators: National Neurological Disorders and Stroke, NIH
    • Evaluation of enaminone anticonvulsants as T-type calcium and sodium channel blockers. Collaborator: Dr. Miguel Martin, UMES School of Pharmacy, Princess Anne, MD
    • Electrophysiology studies of anticonvulsant enaminones as positive GABAergic modulators. Collaborator: Dr. Thomas Heinbockel, Howard University, Department of Anatomy, Washington, DC
    • Computational docking studies of potential enaminone anticonvulsant agents at various epilepsy related molecular targets. Collaborator: Dr. YaYin Fang, Howard University, College of Medicine, Washington, DC