News article synopsis - Dr. Kharel | University of Maryland Eastern Shore Marketing Retarget Pixel

News article synopsis - Dr. Kharel

  • “Many abandoned underground coal mines are burning for years following the trigger of ignitions (e.g. lightning strike). Partially combusted gases build up pressure and eventually make their way through the vents that follows the entry of oxygen-rich fresh air into the burning mine. Notably, continuation of this process for years has altered the surface environment around the vent both in terms of temperature and chemical composition. Research team at the University of Kentucky Center for Pharmaceutical Research and Innovation (CPRI) envisioned that inhabiting microbes-a well-known source of human therapeutics- may have evolved over time to be capable of producing potentially new therapeutic agents. As hypothesized, the collaborative project has led to the discovery of more than 100 microbial metabolites, many of which have demonstrated great therapeutic promise. The research was directed by Prof. Jon Thorson at the University of Kentucky Center for Pharmaceutical Research and Innovation (CPRI) where UMES faculty Dr. Kharel contributed to the project in the capacity of a lead scientist. The project was briefly covered by the news outlet “The Atlantic”.”